Ten years after the explosion of Flight 180, nine years after the pile-up on Route 23 and four years after theDevil's Flight roller coster accident, Nick O'Bannon (Bobby Campo) has a premonition in which a number of people die when McKinley Speedway collapses following a crash. Nick panics, persuading his girlfriend, Lori Milligan (Shantel VanSanten) their friends, Janet Cunningham (Haley Webb) and Hunt Wynorski (Nick Zano), security guard George Lanter (Mykelti Williamson), mechanic Andy Kewzer (Andrew Fiscella), motherSamantha Lane (Krista Allen), racist Carter Daniels (Justin Welborn), and Andy's girlfriend Nadia Monroy(Stephanie Honoré) to leave, escaping seconds before Nick's vision becomes a reality. As Nick is explaining what he saw to the survivors, a stray tire strikes and kills Nadia.
Just days after the collapse, Carter and Samantha die in freak accidents. When Nick and Lori hear of the deaths, they learn about the three previous disasters and realize that Death never meant for them to survive and is now coming for them.
While Janet and Hunt refuse to believe, Nick convinces George and Lori to help him conquer Death's plan. The group is unable to save Andy, but Nick gets new visions and they split up to save Hunt and Janet. Lori and George succesfully rescue Janet from a malfunctioning car wash, but Nick arrives at the pool to late to save Hunt, who dies when he's unable to pull himself free from the pool's vacuum system.
George considers suicide but is unable to kill himself, leading the survivors to believe that saving Janet had stopped Death's plan. Nick decides to take Lori on a holiday, but she has already gone to the mall with Janet. While at the theater, Lori begins to see odd warnings suggesting they are not out of danger as he realizes that there was an additional survivor: Jonathan Grove (Jackson Walker). Jonathan is killed before Nick and George can make it to the hospital, and George is run over by an ambulance shortly thereafter.
Left on his own, Nick arrives at the theater just in time to save Lori from an explosion that kills Janet and several others. However another explosion causes the mall to collapse, and Lori is killed. Just as he dies, Nick awakens outside the hospital and realizes it was all a vision, but is not able to save George from his fate. Thanks to his vision, Nick is able to locate the source of the initial explosion and extinguish the flames before anyone is hurt.
Two weeks later, the trio celebrates their survival in a cafe. Nick begins to take notice of new omens surrounding him, and begins to muse that perhaps it was Death that had been sending him premonitions all along. Just as he says this, a series of events cause a semi to crash through the front of the cafe, killing all three.
